# Medicine
## Links (Wikipedia order)
<!-- injected from _registry/childlinks/Medicine.json (2026-07-30T02:09:12Z) -->
`1st_millennium_BC` · `A_Short_History_of_Christianity` · `Abdomen` · `Access_to_medicines` · `Addiction_medicine` · `Addiction_psychiatry` · `Adolescent_medicine` · `Adolfo_Lutz` · `Al-Ma'mun` · `Albert_Edelfelt` · `Alexander_Fleming` · `Alexandre_Yersin` · `Allergy` · `Allied_health_professionals` · `Alternative_medicine` · `Amateur` · `Ambulatory_care` · `American_English` · `Ampoule` · `Anatomical_pathology` · `Anatomy` · `Ancient_Egyptian_medicine` · `Ancient_Greek_medicine` · `Andrea_Cesalpino` · `Andreas_Vesalius` · `Andrology` · `Anesthesiology` · `Angiology` · `Animism` · `Anthropology` · `Antibiotic` · `Antonie_van_Leeuwenhoek` · `Applied_science` · `Arabic` · `Arsphenamine` · `Art` · `Asaph_the_Jew` · `Asclepieion` · `Aspirin` · `Assay` · `Atropine` · `Auscultation` · `Autonomy` · `Averroes` · `Aviation_medicine` · `Avicenna` · `Ayurveda` · `Azo_dye` · `Bachelor_of_Medical_Sciences` · `Bachelor_of_Medicine,_Bachelor_of_Surgery` · `Bariatric_surgery` · `Bariatrics` · `Beneficence_(ethics)` · `Berlin` · `Bimaristan` · `Biochemistry` · `Biology` · `Biomechanics` · `Biomedical_sciences` · `Biophysics` · `Biopsy` · `Biostatistics` · `Biotechnology` · `Black_Death` · `Blood_pressure` · `Blood_test` · `Blood_vessel` · `Bloodletting` · `Brain` · `British_English` · `Bronze_Age` · `Burkina_Faso` · `Byzantine_Empire` · `Canada` · `Cardiac_surgery` · `Cardiology` · `Cardiothoracic_surgery` · `Cardiovascular_disease` · `Catholic_Church` · `Catholic_Church_and_health_care` · `Cell_(biology)` · `Cell_biology` · `Charlatan` · `Charlemagne` · `Chief_complaint` · `Childbirth` · `Claude_Bernard` · `Claude_Bourgelat` · `Clinic` · `Clinical_chemistry` · `Clinical_neurophysiology` · `Clinical_pathology` · `Clinical_pharmacology` · `Clinical_psychology` · `Colorectal_surgery` · `Commonwealth_of_Nations` · `Community_health` · `Conservation_medicine` · `Continuing_medical_education` · `Continuum_International_Publishing_Group` · `Convalescence` · `Cranial_nerves` · `Credential` · `Cultural_studies` · `Culture` · `Cytogenetics` · `Cytopathology` · `DNA_replication` · `De_materia_medica` · `Dentistry` · `Dermatology` · `Diabetes` · `Diabetic_ketoacidosis` · `Diagnosis` · `Diet_(nutrition)` · `Dietitian` · `Differential_diagnosis` · `Digestive_system_surgery` · `Digoxin` · `Dilemma` · `Directive_2005/36/EC` · `Disaster_medicine` · `Disease` · `Divination` · `Diving_medicine` · `Doctor_of_Medicine` · `Doctor_of_Osteopathic_Medicine` · `Doctors'_Trial` · `Domenico_di_Bartolo` · `Dorland's_medical_reference_works` · `Ear` · `Early_Middle_Ages` · `Ebers_Papyrus` · `Ebla` · `Edward_Jenner` · `Edwin_Smith_Papyrus` · `Egyptian_medical_papyri` · `Electroencephalography` · `Electromyography` · `Electron_microscope` · `Electronic_health_record` · `Elizabeth_Blackwell` · `Embryology` · `Emergency_department` · `Emergency_medical_technician` · `Emergency_medicine` · `Emilie_Savage-Smith` · `Encyclopædia_Britannica` · `Endemic_(epidemiology)` · `Endocrine_surgery` · `Endocrinology` · `Endoscopy` · [[Engineering]] · `Environmental_medicine` · `Ephedrine` · `Epidemiology` · `Ethics` · `Etiology` · `Evidence-based_medicine` · `Evoked_potential` · [[Evolution]] · `Evolutionary_medicine` · `Expedition_medicine` · `Eye` · `Eye_surgery` · `Family_history_(medicine)` · `Family_medicine` · `Family_tree` · `Finland` · `Florence_Nightingale` · `Flow_cytometry` · `Forensic_medicine` · `Francis_Crick` · `Fringe_science` · `Fungus` · `Gabriele_Falloppio` · `Galen` · `Gamma_camera` · `Gastroenterology` · `Gene` · `General_practice` · `General_surgery` · `Genetic_disorder` · `Genetics` · [[Genomics]] · `Geoffrey_Blainey` · `Geriatrics` · `Germany` · `Glossary_of_medicine` · `Greek_language` · `Greeks` · `Gross_anatomy` · `Gynaecology` · `Gynecologic_oncology` · `HEENT_examination` · `Hand_surgery` · `Harvey_Cushing` · `Health` · `Health_care` · `Health_care_rationing` · `Health_economics` · `Health_education` · `Health_informatics` · `Health_insurance` · `Health_professional` · `Health_promotion` · `Heart` · `Heart_failure` · `Hematology` · `Hepato-pancreato-biliary_surgery` · `Hepatology` · `Herman_Boerhaave` · `Hippocrates` · `Hippocratic_Oath` · `Histology` · `History_of_medicine` · `History_of_science` · `History_of_the_present_illness` · `Honesty` · `Hospice` · `Hospital` · `Hospital_medicine` · `Howard_Florey` · `Huangdi_Neijing` · `Human_anatomy` · `Human_evolution` · `Human_genetics` · `Human_skin` · `Human_spaceflight` · `Humanities` · `Humorism` · `Hyperbaric_medicine` · `Iatrogenesis` · `Ibn_Zuhr` · `Ibn_al-Nafis` · `Imhotep` · `Immune_system` · `Immunohistochemistry` · `Immunology` · `Indian_subcontinent` · `Infection` · `Infectious_diseases_(medical_specialty)` · [[Information_science]] · `Information_technology` · `Informed_consent` · `Injury` · `Intensive_care_medicine` · `Internal_medicine` · `Interventional_cardiology` · `Interventional_radiology` · `Ionizing_radiation` · `Jean-Martin_Charcot` · `Kahun_Gynaecological_Papyrus` · `Karachi` · `Karl_Landsteiner` · `Kitasato_Shibasaburō` · `Kokopo` · `Laser_medicine` · `Latin` · `Lifestyle_medicine` · `List_of_causes_of_death_by_rate` · `List_of_disorders` · `Lists_of_diseases` · `Literature` · `Lorsch_Pharmacopoeia` · `Louis_Pasteur` · `MD–PhD` · `Malnutrition` · `Managed_care` · `Marguerite_Martyn` · `Mass_gathering_medicine` · `Master_of_Medicine` · `Master_of_Surgery` · `Maternal–fetal_medicine` · `Maurice_Wilkins` · `Mechanics` · `Medical_Decision_Making_(journal)` · `Medical_News_Today` · `Medical_Scientist_Training_Program` · `Medical_anthropology` · `Medical_billing` · `Medical_classification` · `Medical_device` · `Medical_diagnosis` · `Medical_doctor` · `Medical_education` · `Medical_encyclopedia` · `Medical_error` · `Medical_ethics` · `Medical_genetics` · `Medical_geology` · `Medical_history` · `Medical_humanities` · `Medical_imaging` · `Medical_journal` · `Medical_laboratory` · `Medical_license` · `Medical_literature` · `Medical_malpractice` · `Medical_microbiology` · `Medical_physicist` · `Medical_physics` · `Medical_prescription` · `Medical_psychology` · `Medical_record` · `Medical_school` · `Medical_sociology` · `Medical_specialty` · `Medical_terminology` · `Medical_test` · `Medication` · `Medicine_(disambiguation)` · `Medicine_in_ancient_Rome` · `Meta-analysis` · `Michael_Servetus` · `Microbiology` · `Microorganism` · `Microscopy` · `Modern_Medicine_(art_exhibition)` · `Modernity` · `Molecular_biology` · `Molecular_medicine` · `Molecular_oncology` · `Moral` · `Moses` · `Nail_clubbing` · `Nanomedicine` · `Narcology` · `Neonatology` · `Nephrology` · `Nerve_conduction_study` · [[Nervous_system]] · `Neurology` · `Neuropsychiatry` · `Neuroradiology` · [[Neuroscience]] · `Neurosurgery` · `New_York_City` · `Nicolaus_Copernicus` · `Nikolai_Korotkov` · `Non-ionizing_radiation` · `Nosokinetics` · `Nosology` · [[Nuclear_magnetic_resonance]] · `Nuclear_medicine` · `Nurse_practitioner` · `Nursing_home` · `Obstetric_anesthesiology` · `Obstetrics` · `Obstetrics_and_gynaecology` · `Occupational_medicine` · `Oncology` · `Ophthalmology` · `Oral_and_maxillofacial_surgery` · `Oral_medicine` · `Organism` · `Organización_Médica_Colegial_de_España` · `Orthopedic_surgery` · `Osteopathic_medicine_in_the_United_States` · `Otorhinolaryngology` · `Otto_Loewi` · `Ouagadougou` · `Outline_of_health` · `Outline_of_medicine` · `Over-the-counter_drug` · `Oxford_English_Dictionary` · `Oxygen_saturation` · `Pain_management` · `Palliative_care` · `Palpation` · `Papua_New_Guinea` · `Past_medical_history` · `Pathology` · `Patient` · `Paul-Louis_Simond` · `Paul_Broca` · `Paul_Ehrlich` · `Paula_Diehr` · `Pediatric_surgery` · `Pediatrics` · `Percussion_(medicine)` · `Perforated_eardrum` · `Peripheral_nervous_system` · `Persians` · `Personalized_medicine` · `Pharmaceutical_medicine` · `Pharmacist` · `Pharmacogenomics` · `Pharmacology` · `Philadelphia` · `Philosophy` · `Philosophy_of_healthcare` · `Phlebology` · `Photobiology` · `Physical_chemistry` · `Physical_examination` · `Physical_medicine_and_rehabilitation` · `Physical_therapy` · `Physician_assistant` · [[Physics]] · `Physiology` · `Pierre_Fauchard` · `Plastic_surgery` · `Podiatry` · `Poison` · `Polymath` · `Polymerase_chain_reaction` · `Polysomnography` · `Population_health` · `Praxis_(process)` · `Prayer` · `Prehistoric_medicine` · `Prescription_drug` · `Preventive_healthcare` · `Primary_care` · `Primary_care_physician` · `Primum_non_nocere` · `Prion` · `Prison_healthcare` · `Profession` · `Professional` · `Professional_ethics` · `Prognosis` · `Proto-Indo-European_language` · `Protozoa` · `Psychiatry` · `Psychologist` · `Psychology` · [[Psychotherapy]] · `Ptolemy` · `Public_health` · `Public_hospital` · `Pulmonary_circulation` · `Pulmonology` · `Pulse` · `Quackery` · `Radiation_therapy` · `Radiobiology` · `Radiology` · `Rectum` · `Relapse` · `Reproductive_endocrinology_and_infertility` · `Reproductive_medicine` · `Reproductive_surgery` · `Residency_(medicine)` · `Respect_for_persons` · `Review_of_systems` · `Rheumatology` · `Robert_Koch` · `Royal_Australasian_College_of_Physicians` · `Royal_College_of_Anaesthetists` · `Royal_College_of_Physicians` · `Royal_College_of_Surgeons_of_England` · `Rudolf_Virchow` · `Rural_health` · `Salvador_Luria` · `Santiago_Ramón_y_Cajal` · `Schola_Medica_Salernitana` · [[Science]] · `Separation_of_prescribing_and_dispensing` · `Sexual_medicine` · `Shamanism` · `Shang_dynasty` · `Side_effect` · `Sleep_medicine` · `Smallpox_vaccine` · `Social_history_(medicine)` · `Social_science` · `Sociology` · `Spain` · `Spinal_cord` · `Spiritualism_(beliefs)` · `Splint_(medicine)` · `Sports_medicine` · `Sri_Lanka` · `State_University_of_New_York_Upstate_Medical_University` · `Statistics` · `Stethoscope` · `Subspecialty` · `Sulfonamide_(medicine)` · `Surgeon's_assistant` · `Surgery` · `Surgical_oncology` · `Surgical_suture` · `Surgical_technologist` · `Sushruta` · `Sushruta_Samhita` · `Syria` · `Systematic_review` · `Tampere` · `Technology` · `Telehealth` · `Telenursing` · `Telepharmacy` · `Telepsychiatry` · `Telepsychology` · `Telerehabilitation` · `Terminal_illness` · `The_Canon_of_Medicine` · `Theophilus_Protospatharius` · `Therapy` · `Timeline_of_medicine_and_medical_technology` · `Tobacco_smoking` · `Tomography` · `Tongue_depressor` · `Torah` · `Toxicology` · `Traditional_Chinese_medicine` · `Traditional_medicine` · `Transfusion_medicine` · `Translation_(biology)` · `Trauma_center` · `Trauma_surgery` · `Travel_medicine` · `Tropical_medicine` · `Truth` · `United_Kingdom` · `United_States` · `Universal_health_care` · `University` · `Unnecessary_health_care` · `Uremia` · `Urinary_system` · `Urogynecology` · `Urology` · `Uroscopy` · `Vaccination` · `Vaccine` · `Variolation` · `Vascular_surgery` · `Venereology` · `Veterinary_medicine` · `Vinca_alkaloid` · `Viroid` · `Virus` · `Visual_arts` · `Warfarin` · [[Wayback_Machine]] · `Weight_loss` · `Western_Roman_Empire` · `Western_world` · `William_Coley` · `William_Harvey` · `William_Osler` · `William_Williams_Keen` · `World_Health_Organization` · `X-ray` · `Zoopharmacognosy`
## From the Real GENERATIVE library (beauty pass)
*Medicine — image hotlinked from Wikimedia Commons (via the Real G.E.N.E.R.A.T.I.V.E. course library, Electronics room). [Details & license](https://commons.wikimedia.org/wiki/File:Flag_of_WHO.svg).*
> Medicine is the science[1] and practice[2] of caring for patients, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. ([Wikipedia](https://en.wikipedia.org/wiki/Medicine))
<!-- BEAUTY-PASS-MEDIA:END -->
<!-- HYDRO-BRIDGE-POINTER:START -->
> 🌊 **↓ 8 Hydrodynamics image bridges** — this page's ties to the Water Room atlas (jump to the section at the bottom).
<!-- HYDRO-BRIDGE-POINTER:END -->
The **MEDICINE** acronym spells eight branches of medicine, in order: **M**icrobiology · **E**ndocrinology · **D**ermatology · **I**mmunology · **C**ardiology · **I**nternal medicine · **N**eurology · **E**pidemiology.
This article is the **worklist**. It was seeded from the link-graph crawl in `M.E.D.I.C.I.N.E..csv` — **2,866 validated Wikipedia links** across the parent pages. Each branch carries a short summary plus the most microsimmable child articles, grouped by p5.js MicroSim pattern and led by a build-first **top-10**.
← Related: [[Physics|PHYSICS]] · REACTION · COSMOS · [[Genomics|GENOMICS]] · FRACTALS · POETICS · GENERATIVE · standards in P5 JS EDITOR · best practices in MicroSim Best Practices · collision control in MicroSim-Registry
*Slug note:* human-readable slugs. *Sheet note:* columns flipped (parent = col A, link = col B); match parents by keyword.
**Status legend:** `- [ ]` unclaimed · `- [x] … *✅ <editor URL>*` shipped.
---
> ## ⚠️ Two notes on this hub
>
> **1. The M (Microbiology) section** ✅ — the sheet crawled only seven of eight parents, so Microbiology was re-crawled live from `Microbiology` and built to 50 microsim topics. Microbiology is also a branch in [[Genomics|GENOMICS]]; the registry shares one article per topic across both hubs.
>
> **2. Clinical medicine is *partly* microsimmable.** Like the life sciences, medicine mixes genuinely dynamic, quantitative **processes** (the cardiac cycle and ECG, hormone [[Feedback|feedback]] loops, glucose–insulin dynamics, the SIR/SEIR epidemic models, pharmacokinetics, nerve conduction) with a vast catalog of **named diseases, syndromes, drugs, anatomy, and procedures** that is *different-visualization* material and is dropped from these worklists.
---
## Overview
**Medicine** is the [[Science|science]] and practice of diagnosing, treating, and preventing disease. The eight MEDICINE branches: Microbiology (microbes, growth, motility, infection), Endocrinology (hormones and feedback), Dermatology (the skin), Immunology (the immune [[System|system]]), Cardiology (the heart and circulation), Internal medicine (adult systemic disease), Neurology (the [[Nervous_system|nervous system]]), and Epidemiology (disease in populations). Each is a "room" with its own worklist below.
| Branch | Letter | Candidate links in sheet | Worklist status |
|--------|:------:|:-----:|-----------------|
| Microbiology | M | re-crawled | ✅ 50 selected |
| Endocrinology | E | 700 | ✅ 62 selected |
| Dermatology | D | re-crawled | ✅ 52 selected |
| Immunology | I | 495 | ✅ 73 selected |
| Cardiology | C | 637 | ✅ 71 selected |
| Internal medicine | I | 117 | ✅ 7 selected ·⚠️ under-seeded |
| Neurology | N | 225 | ✅ 18 selected ·⚠️ under-seeded |
| Epidemiology | E | 611 | ✅ 117 selected |
---
## M — Microbiology
**50 articles** selected from a live Chrome re-crawl of **`Microbiology`** (+ `Bacterial growth`, `Bacterial cell structure`, `Bacteriophage`, `Quorum sensing`, `Chemotaxis`, `Horizontal gene transfer`), grouped by MicroSim pattern and led by a build-first top-10. Microbiology is richly microsimmable as agent and field models: a growth curve is a logistic population, motility is run-and-tumble agents, chemotaxis is agents climbing a gradient, a biofilm is a growing colony, gene transfer is a contact network. Dropped as named species / people / off-theme: the genera and strains (*E. coli*, *B. subtilis*, *S. aureus*, *Enterococcus*, *Lactococcus*), the microbiologists (Leeuwenhoek, Kircher, Avicenna, Pasteur, Koch), societies (ASM), the ecology navbox (which routes to GENOMICS/Ecology), and `*_(identifier)`/glossary cruft. Topics shared with GENOMICS/Microbiology are one-article-per-topic via the registry.
### Top 10 — start here (10) · *the canonical microbiology sims*
- [ ] Bacterial growth
- [ ] Binary fission
- [ ] Bacterial flagellum
- [ ] Chemotaxis
- [ ] Biofilm
- [ ] Gram stain
- [ ] Agar plate
- [ ] Antimicrobial resistance
- [ ] Bacteriophage
- [ ] Bacterial conjugation
### Growth, division & culture (9)
- [ ] Chemostat
- [ ] Cell division
- [ ] Enrichment culture
- [ ] Colony (biology)
- [ ] Colonial morphology
- [ ] Colony-forming units
- [ ] Industrial fermentation
- [ ] Aerobic organism
- [ ] Anaerobic organism
### Motility & chemotaxis (9)
- [ ] Bacterial motility
- [ ] Flagellum
- [ ] Flagellin
- [ ] Flagellar motor switch
- [ ] Gliding motility
- [ ] Chemotaxis assay
- [ ] Intraflagellar transport
- [ ] Bacteria collective motion
- [ ] Amoeboid movement
### Cell structure & morphology (13)
- [ ] Bacterial cell structure
- [ ] Bacterial cell wall
- [ ] Cell wall
- [ ] Bacterial capsule
- [ ] Bacterial outer membrane
- [ ] Cell membrane
- [ ] Cytoskeleton
- [ ] Endospore
- [ ] Bacterial cellular morphologies
- [ ] Bacterial morphological plasticity
- [ ] Coccus
- [ ] Coccobacillus
- [ ] Bacillus (shape)
### Gene transfer & communication (5)
- [ ] Horizontal gene transfer
- [ ] Conjugation (biochemistry)
- [ ] Gene transfer agent
- [ ] [[Quorum_sensing]]
- [ ] Interspecies quorum sensing
### Antibiotics & infection (4)
- [ ] Antibiotic
- [ ] Beta-lactam antibiotic
- [ ] Aminoglycoside antibiotics
- [ ] [[Diffusion]]
## E — Endocrinology
Endocrinology is the study of hormones and the glands that secrete them — the body's slow, chemical [[Control_system|control system]], in which a gland releases a signaling molecule into the blood, a distant target reads its concentration, and the response feeds back to throttle the original gland. That [[Architecture|architecture]] makes it the most microsimmable branch of clinical medicine: nearly every core idea is a **feedback loop** (the hypothalamic–pituitary axes, glucose and calcium regulation, thermoregulation) or a **dose–response curve** (a hormone's effect rising and saturating with concentration, receptor occupancy, second-messenger amplification). A learner can drag a set-point, inject a hormone, block a receptor, or perturb iodine intake and watch the regulated variable overshoot, settle, or run away.
**62 articles** selected from the **701** validated candidates — the largest pool in the sheet — by the clinical bar *"is this a dynamic, quantitative process or model, not a named disease, drug, organ, or person?"*, grouped by p5.js MicroSim pattern and led by a build-first top-10. The pool was heavily diluted and most of it dropped: the bulk of the 701 were the disease-template catalogs that every endocrine page carries — **named diseases and syndromes** (diabetes and its complications, the MODY 1–6 series, every thyroiditis and goitre variant, the congenital adrenal hyperplasias, Cushing's, Conn's, Addison's, Graves', Kallmann, Bartter, Liddle, the eponymous exophthalmos *signs*, the lipid- and growth-disorder rosters, the vitamin- and mineral-deficiency rosters) — plus **anatomy and cell types** (the pituitary lobes and their acidophil/basophil/corticotrope cells, the adrenal zonae, the pancreatic islet α/β/δ/ε cells, gonads and ducts), **procedures and lab tests** (thyroidectomy, adrenalectomy, hypophysectomy, the dexamethasone/ACTH/TRH/captopril suppression and stimulation tests), the entire **Template:Medicine specialty roster** (every surgical and internal subspecialty), **people** (Galen, Hippocrates, Aristotle, Berthold, Addison, Graves, Bayliss, Starling, Minkowski, Loewi, Sutherland), **organizations and journals** (the Endocrine [[Society]], the ADA, *Endocrinology*), and the usual `*_(identifier)`, `Category:*`, `Template_talk:*`, and `List_of_/History_of_` cruft. Those were dropped as diseases / drugs / anatomy / procedures / specialties / people / cruft rather than padded in, leaving a focused set of feedback loops, regulatory models, signaling mechanisms, and the hormones that act as their agents. Synonym twins were collapsed to one slug each (Blood_sugar / Blood_glucose → `Blood_sugar_level`).
### Top 10 — start here (10) · *the most canonical, visually striking endocrine sims; build these first*
- [ ] Hypothalamic–pituitary–thyroid axis
- [ ] Hypothalamic–pituitary–adrenal axis
- [ ] Blood sugar regulation
- [ ] [[Homeostasis]]
- [ ] Hypothalamic–pituitary–gonadal axis
- [ ] Renin–angiotensin system
- [ ] Calcium metabolism
- [ ] Insulin
- [ ] Cyclic adenosine monophosphate
- [ ] Thermoregulation
### Endocrine feedback axes (3) · *feedback-loop; close the hypothalamus → pituitary → gland → hormone loop and watch it self-correct*
- [ ] Hypothalamic–pituitary–somatotropic axis
- [ ] Hypothalamic–pituitary–prolactin axis
- [ ] Hypothalamic–neurohypophyseal system
### Homeostasis & metabolic regulation (5) · *set-point / dynamical-system; tune the input and watch the regulated variable settle, overshoot, or run away*
- [ ] Metabolism
- [ ] Insulin resistance
- [ ] Pancreatic beta cell function
- [ ] Blood sugar level
- [ ] Glucose
### Hormone families & classes (12) · *catalog / builder; sort hormones by chemistry and target, then build the signaling molecule*
- [ ] Hormone
- [ ] Peptide hormones
- [ ] Steroid hormones
- [ ] Sex hormone
- [ ] Catecholamines
- [ ] Gonadotropin
- [ ] Neurohormone
- [ ] Glucocorticoid
- [ ] Mineralocorticoid
- [ ] Androgen
- [ ] Estrogen
- [ ] Progestogen
### Hormones as feedback & dose–response agents (18) · *agent / parameter; release the hormone, sweep its dose, read the target response and the feedback it triggers*
- [ ] Growth hormone
- [ ] Thyroid hormone
- [ ] Thyroid-stimulating hormone
- [ ] Thyrotropin-releasing hormone
- [ ] Follicle-stimulating hormone
- [ ] Triiodothyronine
- [ ] Corticotropin-releasing hormone
- [ ] Cortisol
- [ ] Aldosterone
- [ ] Testosterone
- [ ] Vasopressin
- [ ] Leptin
- [ ] Ghrelin
- [ ] Secretin
- [ ] Norepinephrine
- [ ] Epinephrine
- [ ] Dopamine
- [ ] Calcitriol
### Cell signaling & second messengers (4) · *cascade / agent; bind the receptor and trace the second-messenger amplification through the cell*
- [ ] Secretion
- [ ] Paracrine
- [ ] Autocrine signaling
- [ ] Intracrine
### Dose–response & receptor binding (2) · *parameter; sweep dose against receptor occupancy and effect along the sigmoid*
- [ ] Androgen receptor
- [ ] Enzyme inhibitor
### Thyroid–iodine regulatory effects (3) · *parameter; push iodine intake up and down and watch the thyroid autoregulate*
- [ ] Wolff–Chaikoff effect
- [ ] Jod-Basedow phenomenon
- [ ] Plummer effect
### Physiological processes under hormonal control (5) · *process; drive a hormonally-controlled rhythm, response, or developmental timeline*
- [ ] Stress (physiology)
- [ ] Sleep
- [ ] Reproduction
- [ ] Lactation
- [ ] Sexual development
## D — Dermatology
Dermatology is the medicine of the skin — the body's largest organ and its barrier to the outside world. Its genuinely microsimmable core is physical and quantitative: light and heat moving through layered tissue — ultraviolet and laser [[Energy|energy]] attenuating with depth, the photochemistry that activates a photosensitizer, and the temperature-times-time integral that denatures tissue when it is burned or frozen — alongside barrier transport, melanin's UV response, and wound-healing kinetics. Almost none of that process layer was surfaced by this crawl, which returned the clinical catalog instead.
**52 articles** — the 5 energy-delivery treatments plus a live Chrome re-crawl of `Skin`, `Human_skin`, `Wound_healing`, `Sunburn`, and `Melanin` — by the clinical bar *"is this a dynamic, quantitative process or model, not a named disease, drug, procedure, organ, or person?"* ✅ **Re-crawled past 50** (skin-specific [[Structure|structure]], pigment, gland, and wound-healing concepts; shared sensory/vascular physiology was left to NEUROLOGY/CARDIOLOGY). The pool is almost entirely non-simulatable clinical material: **named diseases and conditions** (eczema, atopic dermatitis, acne, melasma, vitiligo, lupus, pemphigus vulgaris, bullous pemphigoid, hypertrichosis, skin cancer, necrotizing fasciitis, Stevens–Johnson syndrome, angioedema, the genodermatoses, `List_of_skin_conditions`), **surgical and diagnostic procedures** (Mohs micrographic surgery and CCPDMA, skin biopsy, dermoscopy, trichoscopy, liposuction, blepharoplasty, face lift, cosmetic surgery, tattoo removal, the tumescent technique, the suction blister, injectable fillers, allergy testing), a **drug** (botulinum toxin), **subspecialties** (dermatopathology, immunodermatology, trichology, teledermatology, pediatric and neonatal dermatology), **people** (Alibert, Frederic Mohs, Jeffrey Klein, `List_of_dermatologists`), **places and organizations** (Hôpital Saint-Louis, the American Academy and Boards of Dermatology, the Royal College of Physicians, even a shopping mall), **journals** (*Dermatology*, *Dermatologic Surgery*), a **classification system** (the ATC system and ATC code D), and the usual `Category:*`, `History_of_`, and `List_of_` cruft. Those were dropped as diseases / procedures / drugs / specialties / people / places / organizations / cruft rather than padded in, leaving only the energy-delivery treatments whose lesson is a genuine biophysical process — light and heat dosing skin. Near-twins were collapsed to one slug (Laser_therapy → `Laser_medicine`; Mohs_surgery folded into the dropped Mohs procedure). **A re-crawl is recommended** from better parents — `Skin`, `Human_skin`, `Wound_healing`, `Sunburn`, `Melanin`, `Transdermal`, `Thermoregulation` — to surface the barrier-transport, pigment, and wound-healing process articles this room should hold.
### Top 10 — start here (10) · *the most canonical, visually striking skin sims*
- [ ] Epidermis
- [ ] Dermis
- [ ] Melanocyte
- [ ] Melanin
- [ ] Hair follicle
- [ ] Sweat gland
- [ ] Keratinocyte
- [ ] Wound healing
- [ ] Stratum corneum
- [ ] Fitzpatrick scale
### Skin layers & structure (8) · *labelled cross-section sim; build the barrier layer by layer*
- [ ] Hypodermis
- [ ] Subcutaneous tissue
- [ ] Stratum basale
- [ ] Basement membrane
- [ ] Dermal papillae
- [ ] Epidermal ridges
- [ ] Skin
- [ ] Skin temperature
### Cells & keratinization (8) · *migration / differentiation sim; ride a cell up from basale to flake-off*
- [ ] Langerhans cell
- [ ] Merkel cell
- [ ] Fibroblast
- [ ] Keratin
- [ ] Keratinization
- [ ] Cornification
- [ ] Desquamation
- [ ] Dermal appendage
### Pigment & UV response (6) · *dose–response sim; tune UV and watch melanin darken*
- [ ] Hyperpigmentation
- [ ] Biological pigment
- [ ] Sun tanning
- [ ] Sunburn
- [ ] Ultraviolet
- [ ] Vitamin D
### Glands & appendages (8) · *gland / follicle schematic sim*
- [ ] Sebaceous gland
- [ ] Sebum
- [ ] Eccrine sweat gland
- [ ] Apocrine sweat gland
- [ ] Perspiration
- [ ] Arrector pili muscle
- [ ] Hair
- [ ] Nail (anatomy)
### Extracellular matrix & wound healing (5) · *kinetics sim; close the wound through its phases*
- [ ] Collagen
- [ ] Collagen fibrils
- [ ] Elastin
- [ ] Granulation tissue
- [ ] Callus
### Barrier transport & treatments (7) · *transport / dose–response sim; light, heat, and drug crossing skin*
- [ ] Transdermal patch
- [ ] Intradermal injection
- [ ] Phototherapy
- [ ] Photodynamic therapy
- [ ] Laser medicine
- [ ] Cryosurgery
- [ ] Burn
## I — Immunology
Immunology is the study of the immune system — the body's distributed, self-updating defense network, in which roving cells and soluble molecules detect non-self, escalate a proportionate response, remember it, and then stand down without attacking the host. That architecture is unusually microsimmable, because almost every core idea is either an **agent-based process** (phagocytes hunting pathogens, leukocytes rolling and squeezing through a vessel wall, clones proliferating in proportion to how well they bind) or a **cascade / threshold model** (the complement cascade, antigen presentation, the affinity-maturation and V(D)J-recombination engines that manufacture receptor diversity, the tolerance checkpoints that decide self from non-self). A learner can release a pathogen, sweep a binding affinity, set a self-reactivity threshold, or tune the cytokine field and watch the population of responders expand, clear the threat, and contract into memory.
**73 articles** selected from the **495** validated candidates by the clinical bar *"is this a dynamic, quantitative process or model, not a named disease, drug, organ, cell type, or person?"*, grouped by p5.js MicroSim pattern and led by a build-first top-10. The pool was dominated by non-simulatable clinical and anatomical material, all dropped: **named diseases and disorders** (rheumatoid arthritis, lupus, Hashimoto's, myasthenia gravis, asthma, Crohn's, HIV/AIDS, the immunodeficiencies, hypersensitivity, transplant rejection, pre-eclampsia, the Plague of Athens), the **entire named cell-type catalog** carried by the `Template:Myeloid_blood_cells` and `Template:Lymphocytes` sidebars (every granulocyte, monocyte, macrophage, dendritic, B-, T-, and NK-cell subset, plus the myeloblast→reticulocyte maturation stages — the differentiation *processes* are kept, the cell stubs are not), **organs and lymphoid anatomy** (thymus, spleen, lymph nodes, tonsils, adenoids, bone marrow, liver, endothelium, the lymphatic system), **lab assays and procedures** (immunoassay, immunoprecipitation, serology, isotopic and fluorescent labeling, immunotherapy, immunosuppression), the whole **`Template:Branches_of_biology` specialty roster** (aerobiology through zoology) and the **`Template:Biology_nav` general-biology concepts** (mitosis, meiosis, photosynthesis, DNA, [[Evolution|evolution]], the plant-tissue and ecology rosters) which are off-theme and owned by [[Genomics|GENOMICS]], **people** (Metchnikoff, Ehrlich, Koch, von Behring, Burnet, Jerne, Matzinger, Thucydides), **organizations and journals** (NIAID, the Nobel Prize, *Immunobiology*), **subspecialties** (clinical immunology, immunogenetics, ecoimmunology, osteoimmunology, reproductive and cancer immunology), the **behavioral / eco-immunology cluster** (disgust, vomiting, the monarch–milkweed–aphid examples, symbiosis), and the usual `Category:*`, `Template_talk:*`, `List_of_*`, `Index_of_*`, `Outline_of_*`, `Timeline_of_*`, `*_(identifier)`, and Wikiversity cruft. Those were dropped as diseases / cell types / anatomy / procedures / specialties / people / off-theme rather than padded in, leaving a focused set of recognition, response, diversity-generation, tolerance, and differentiation processes plus the molecular agents that drive them. Synonym twins were collapsed to one slug each (Immunoglobulin → `Antibody`, Adaptive_immune_system → `Adaptive_immunity`, Complement_cascade → `Complement_system`, Clonal_selection_theory → `Clonal_selection`). Topics shared with [[Genomics|GENOMICS]]-Immunology are listed here too and built once by the registry.
### Top 10 — start here (10) · *agent / cascade / binding; the most canonical, visually striking immune sims — build these first*
- [ ] Clonal selection
- [ ] Phagocytosis
- [ ] Complement system
- [ ] Inflammation
- [ ] Antibody
- [ ] Antigen
- [ ] Antigen presentation
- [ ] Leukocyte extravasation
- [ ] V(D)J recombination
- [ ] Affinity maturation
### Immunity types & the response over time (9) · *dynamical system / agent; switch between the innate and adaptive arms and watch the response build, peak, and settle into memory*
- [ ] Immune system
- [ ] Innate immunity
- [ ] Adaptive immunity
- [ ] Humoral immunity
- [ ] Cell-mediated immunity
- [ ] Immunity (medical)
- [ ] Passive immunity
- [ ] Intrinsic immunity
- [ ] Vaccination schedule
### Innate effectors & pathogen clearance (5) · *agent / cascade; tag, lyse, and clump pathogens, then watch them cleared*
- [ ] Opsonin
- [ ] Cytolysin
- [ ] Agglutination (biology)
- [ ] Immune complex
- [ ] Pathogen
### Adhesion & cytokine signaling (6) · *field / gradient / agent; roll, adhere, and follow chemokine gradients into the tissue*
- [ ] Cell adhesion molecule
- [ ] Integrin
- [ ] Selectin
- [ ] Cytokine
- [ ] Downregulation and upregulation
- [ ] Co-stimulation
### Antigen recognition & presentation (3) · *matching / lock-and-key; present peptides on MHC and test self versus non-self*
- [ ] Major histocompatibility complex
- [ ] Histocompatibility
- [ ] Superantigen
### Antibody–antigen binding (10) · *lock-and-key / parameter; dock a paratope to its epitope and sweep affinity and cross-reactivity*
- [ ] Epitope
- [ ] Linear epitope
- [ ] Conformational epitope
- [ ] Mimotope
- [ ] Paratope
- [ ] Hapten
- [ ] Allergen
- [ ] Immunogen
- [ ] Affinity (pharmacology)
- [ ] Cross-reactivity
### Antibody classes & clonal repertoire (8) · *catalog / builder; assemble isotypes and mono- versus polyclonal responses*
- [ ] Monoclonal antibody
- [ ] Polyclonal antibodies
- [ ] Autoantibody
- [ ] Microantibody
- [ ] Allotype (immunology)
- [ ] Isotype (immunology)
- [ ] Idiotype
- [ ] Polyclonal B cell response
### Repertoire diversity generation (4) · *combinatorial / stochastic; recombine, mutate, and switch to build a receptor repertoire*
- [ ] Somatic hypermutation
- [ ] Junctional diversity
- [ ] Immunoglobulin class switching
- [ ] Antigenic variation
### Tolerance & autoimmunity (9) · *selection / threshold; set the self-reactivity threshold and watch tolerance hold or break*
- [ ] Immune tolerance
- [ ] Central tolerance
- [ ] Peripheral tolerance
- [ ] Clonal anergy
- [ ] Clonal deletion
- [ ] Immune privilege
- [ ] Immune tolerance in pregnancy
- [ ] Autoimmunity
- [ ] Alloimmunity
### Haematopoiesis & lineage differentiation (9) · *branching tree / lineage; tune the cytokines and steer stem cells down the blood-cell tree*
- [ ] Haematopoiesis
- [ ] Myelopoiesis
- [ ] Granulopoiesis
- [ ] Monocytopoiesis
- [ ] Thrombopoiesis
- [ ] Erythropoiesis
- [ ] Lymphopoiesis
- [ ] Extramedullary hematopoiesis
- [ ] Thymic involution
## C — Cardiology
Cardiology is the medicine of the heart and the circulation it drives — a muscular pump whose every beat is at once an electrical [[Wave|wave]], a pressure pulse, and a sound, repeated a hundred thousand times a day. That makes it the most *physically* microsimmable branch of clinical medicine: where endocrinology is feedback loops and immunology is agents, cardiology is **waves and circuits**. An action potential sweeps across pacemaker and conduction tissue and sets the rhythm; the ECG, the phonocardiogram, the arterial pulse, and the jugular venous trace are all that one cardiac event read out through different instruments; blood flows through branching loops at a pressure set by flow times resistance; and a fibrillating ventricle is a sheet of excitable media broken into spiral waves that a defibrillating shock resets to rest. A learner can scrub through the cardiac cycle, pace a strip of tissue, block a node and watch the rhythm fall apart, sweep a stenosis and watch the jet accelerate, slide the QRS axis around the hexaxial reference, or shock a fibrillating heart back to sinus.
**71 articles** selected from the **637** validated candidates by the clinical bar *"is this a dynamic, quantitative process or model, not a named disease, drug, organ, procedure, or person?"*, grouped by p5.js MicroSim pattern and led by a build-first top-10. The pool was overwhelmingly clinical and most of it — 566 of the 637 — was dropped, because every cardiology page carries the disease, device, procedure, and eponym catalogs: the **named diseases** (the coronary syndromes and myocardial infarction, heart failure, the cardiomyopathies and the endo-/myo-/pericarditides, the valve stenoses and regurgitations, the congenital defects from tetralogy of Fallot to transposition of the great arteries, hypertension and atherosclerosis, and the long roster of named tachy- and brady-arrhythmias, blocks, and long-QT syndromes), the **devices and procedures** (pacemakers and ICDs, stents and catheters, angioplasty and bypass, the valve replacements and the whole congenital-repair roster from Blalock–Taussig to Fontan, ablation, transplantation), the **imaging and lab modalities** that are procedures rather than processes (cardiac CT and MRI, perfusion scans and ventriculography, Holter and stress testing, the lipid panel), **anatomy** (the chambers and valves, the myocardium and coronary veins, and the entire arteries-and-veins template down to the vasa vasorum), the eponymous **signs** (Levine's, De Musset's, Janeway, Osler, Beck's triad, Kussmaul), the **people** (Harvey, Einthoven, Forssmann, Blalock and Taussig and Thomas, Lown, Wenckebach), the **societies and journals** (the ACC, AHA, and ESC; *Circulation* and the *European Heart Journal*), the **risk-factor and epidemiology** tail (smoking, obesity, the RCTs and mortality statistics), and the usual `Category:*`, `Template_talk:*`, `List_of_*`, and `Outline_of_*` cruft. Those were dropped as diseases / devices / procedures / anatomy / signs / people / off-theme rather than padded in, leaving a focused set of the electrical, mechanical, acoustic, and hemodynamic *processes* that genuinely animate. Synonym twins were collapsed to one slug each (ECG / Electrocardiograms → `Electrocardiography`; Echocardiogram → `Echocardiography`; Cardiac_conduction_system → `Electrical_conduction_system_of_the_heart`). Topics shared with other hubs — the action potential with [[Genomics|GENOMICS]]-Neuroscience, fluid mechanics with [[Physics|PHYSICS]] — are listed here too and built once by the registry.
### Top 10 — start here (10) · *wave / circuit / pump; the most canonical, visually striking cardiology sims — build these first*
- [ ] Cardiac cycle
- [ ] Action potential
- [ ] Electrical conduction system of the heart
- [ ] Electrocardiography
- [ ] Cardiac pacemaker
- [ ] Heart sounds
- [ ] Blood pressure
- [ ] Fibrillation
- [ ] Defibrillation
- [ ] Pulse
### Conduction, automaticity & arrhythmia mechanisms (10) · *excitable-media / competing-oscillators; fire a focus, race two pacemakers, block a node, and break the wave into fibrillation*
- [ ] Cardiac electrophysiology
- [ ] Heart block
- [ ] Ectopic pacemaker
- [ ] Ectopic beat
- [ ] Premature heart beat
- [ ] Premature atrial contraction
- [ ] Premature ventricular contraction
- [ ] Premature junctional contraction
- [ ] Parasystole
- [ ] Wandering atrial pacemaker
### The ECG: waves, intervals & segments (7) · *waveform; build the trace deflection by deflection and shift the intervals and segments*
- [ ] QT interval
- [ ] T wave
- [ ] T wave alternans
- [ ] ST segment
- [ ] ST elevation
- [ ] ST depression
- [ ] J wave
### Cardiac electrical axis & vector loops (4) · *vector / geometry; sum the depolarization vectors and read the axis off the hexaxial reference*
- [ ] Hexaxial reference system
- [ ] Right axis deviation
- [ ] Left axis deviation
- [ ] Vectorcardiography
### Heart sounds & murmurs (11) · *acoustic-timing; place the events in the cardiac cycle and hear systole and diastole fill with sound*
- [ ] Split S2
- [ ] Third heart sound
- [ ] Fourth heart sound
- [ ] Gallop rhythm
- [ ] Heart murmur
- [ ] Systolic heart murmur
- [ ] Diastolic heart murmur
- [ ] Continuous murmurs
- [ ] Heart click
- [ ] Bruit
- [ ] Pericardial friction rub
### The arterial pulse & venous waveforms (7) · *pressure-waveform; shape the pulse contour and read the a/c/v waves of the venous trace*
- [ ] Pulsus paradoxus
- [ ] Pulsus bisferiens
- [ ] Pulsus bigeminus
- [ ] Pulsus alternans
- [ ] Collapsing pulse
- [ ] Jugular venous pressure
- [ ] Cannon A waves
### The cardiac cycle as a pump (4) · *mechanical-cycle / parameter; tune rate, afterload, and the systolic interval and watch the pump respond*
- [ ] Systole (medicine)
- [ ] Afterload
- [ ] Heart rate
- [ ] Pump
### Blood pressure, flow & the circulatory loops (10) · *flow / circuit; drive blood through the systemic, pulmonary, coronary, and capillary loops and watch pressure, resistance, and a stenotic jet respond*
- [ ] Blood pressure measurement
- [ ] Systemic circulation
- [ ] Pulmonary circulation
- [ ] Coronary circulation
- [ ] Microcirculation
- [ ] Fluid mechanics
- [ ] Stenosis
- [ ] Hyperaemia
- [ ] Ischemia
- [ ] Shock (circulatory)
### Cardiac signal modalities beyond the ECG (4) · *signal-over-time; capture the same heartbeat as a sound, a magnetic field, an impedance, and a recoil*
- [ ] Phonocardiogram
- [ ] Magnetocardiography
- [ ] Impedance cardiography
- [ ] Ballistocardiography
### Imaging & resuscitation dynamics (4) · *wave-imaging / reset; bounce ultrasound off the moving heart, read the Doppler shift, and time the shock that restarts it*
- [ ] Echocardiography
- [ ] Doppler ultrasound
- [ ] Cardioversion
- [ ] Cardiopulmonary resuscitation
## I — Internal medicine
Internal medicine is the care of adults with complex, often multi-system disease — the generalist discipline that diagnoses and manages illness across every organ system without surgery. Unlike endocrinology or cardiology, the Wikipedia parent that seeded this room is almost entirely about the *profession* rather than the *physiology*: training pathways, subspecialties, and the royal colleges and boards that credential them. Its genuinely microsimmable core is therefore thin and lives in two places — the quantitative logic of **diagnosis** (test sensitivity and specificity, pre-test versus post-test probability, weighing competing diagnoses) and a handful of **physiological transport and mechanics** processes (solute clearance across a dialysis membrane, the pressure–volume–flow mechanics of mechanical ventilation, and the acoustic-wave echo of ultrasound). A learner can slide a decision threshold along two overlapping distributions and watch the ROC point move, sweep a likelihood ratio and watch a diagnosis's probability climb, or tune membrane area, tidal volume, or probe frequency and watch clearance, a pressure–volume loop, or an echo respond.
**7 articles** ⚠️ **under-seeded** — selected from the **117** validated candidates by the clinical bar *"is this a dynamic, quantitative process or model, not a named disease, drug, organ, procedure, specialty, organization, or person?"*. After filtering, the 117-link crawl fell far below the 50-item minimum, so the branch is flagged; every kept item genuinely clears the bar and nothing was padded in. The pool was overwhelmingly non-simulatable professional and clinical material, all dropped: the **medical-specialty roster** (geriatric, critical-care, palliative, rehabilitation, renal, respiratory, sport, acute, audiovestibular, and genitourinary medicine; clinical genetics, pharmacology, and pharmacy; medical and neuro-oncology; haematology; pulmonary and infectious-disease specialties), the **training and credentialing ladder** (internship, foundation and senior-house-officer posts, core medical training, residency, fellowship, the medical degree, licensure, MRCP), the **royal colleges, boards, and councils** (the American College of Physicians, the Royal Colleges of Physicians of Edinburgh and of Glasgow, the Australasian, Canadian, and New Zealand colleges and councils, the UEMS, AHPRA, the GMC), **organs and anatomy** (lungs, respiratory tract, blood vessels, organ systems, the cadaver), **named diseases and categories** (allergies, digestive and infectious diseases, rheumatic and chronic disease, multisystem and acute illness), **procedures and devices** (cardiac ablation, endoscopy, ERCP, bronchoscopy, the intra-aortic [[Balloon|balloon]] pump), a **drug** class (medication), **pathogens** (bacterium, parasite, biological agent), **people** (Sydenham, Morgagni, Charaka), **places and traditions** (Ancient India and China, Ayurveda, the Commonwealth, the EU), **medical-ethics principles** (beneficence, non-maleficence, justice), care-delivery and IT concepts (inpatient, ambulatory, and primary care, telehealth, the electronic health record), and the usual `Category:*`, `Etymology`, and `Wayback_Machine` cruft. Those were dropped as specialties / training / organizations / anatomy / diseases / procedures / drugs / people / places / ethics / cruft rather than padded in. **A re-crawl is recommended** from better parents — `Homeostasis`, `Acid–base homeostasis`, `Pharmacokinetics`, `Renal physiology`, `Fluid balance`, `Electrolyte`, and `Oxygen–hemoglobin dissociation curve` — to surface the compartment-model, balance, and clearance processes this room should hold (note `Homeostasis` already lives in the Endocrinology room).
### Top 4 — start here (4) · *the most canonical, visually striking internal-medicine sims; build these first*
- [ ] Sensitivity and specificity
- [ ] Kidney dialysis
- [ ] Mechanical ventilation
- [ ] Ultrasound
### Diagnostic reasoning & test statistics (2) · *Bayesian / probability-update; sweep the likelihood ratio and watch competing diagnoses rise and fall*
- [ ] Differential diagnosis
- [ ] Medical test
### Disease course over time (1) · *stage-progression timeline; advance a cohort through the stages of illness*
- [ ] Natural history of disease
## N — Neurology
Neurology is the medicine of the nervous system — the brain, spinal cord, nerves, and muscles, and the disorders that disrupt them. Its genuinely microsimmable core is the same excitable, electrical physiology that basic neuroscience studies, seen through the clinic's instruments: an impulse propagating down an axon at a conduction [[Velocity|velocity]] a nerve-conduction study can time, the motor-unit trains an EMG records, the rhythmic brain waves an EEG draws, the stimulus-locked evoked potential, the reflex arc that fires before thought, and the feedback control behind a steady gait. Above the single cell sit circuits, connectomes, and the decoders that turn spikes into intent — the substrate of brain–computer interfaces — together with the slow processes of plasticity, neuromodulation, and neurodevelopment. A learner can stimulate a nerve and read off the latency, set a detection threshold and sweep the ROC, or tune a network and watch it learn.
**18 articles** selected from the **225** validated candidates by the clinical bar *"is this a dynamic, quantitative process or model, not a named disease, drug, anatomy, procedure, specialty, or person?"*, grouped by p5.js MicroSim pattern and led by a build-first top-10. ⚠️ **Under-seeded.** Unlike the basic-science [[Genomics|GENOMICS]]-Neuroscience crawl, `Neurology` is a *clinical-specialty* page, and its link graph is overwhelmingly non-simulatable: the single largest block is the **`Template:Neuroscience` navbox** — roughly seventy "neuro-X" sub-discipline and applied-field names (computational, cognitive, molecular, cellular, systems, behavioral, clinical, social, affective, cultural, evolutionary neuroscience; neuroeconomics, neurolaw, neuroethics, neuromarketing, neurophilosophy, neuroaesthetics …), each a discipline rather than a sim and dropped exactly as the "-genetics" subfields were in the **G** room — plus **named diseases and disorders** (Parkinson's, Alzheimer's, Huntington's, epilepsy, multiple sclerosis, the dementias, the neuropathies, the muscular dystrophies, migraine, brain tumors, traumatic brain injury and its sequelae, the neurodegenerative and neurodevelopmental disorders), **brain and nerve anatomy** (the hippocampus, spinal cord, cranial nerves, the peripheral / sensory / enteric nervous systems, cerebrospinal fluid, the dendrite), **imaging and diagnostic procedures** (CT, MRI, lumbar puncture, the neurological examination, genetic testing, neuroimaging, intraoperative monitoring), **subspecialties and roles** (neuromuscular and pain medicine, behavioral neurology, physiatry, electrodiagnostic medicine, the neurosurgeon, neurointensivist, and physiotherapist), **people** (Willis, Whytt, Baillie, Bell, Romberg, Duchenne, Hammond, Charcot, Hughlings Jackson, Fisher, Flatau), **organizations, boards, journals, and credentials** (the American Board of Psychiatry and Neurology, *Neurology*, *Developmental Neurorehabilitation*, MBBS, MRCPsych, Queen Square, Harvard Medical School, the Joint Commission), broad **cognitive and clinical nouns** with no in-pool model (cognition, human behavior, pain, aging, biomarker, clinical / translational research), and the usual `Category:*`, `Template_talk:*`, `List_/Outline_/History_of_*`, and `*_(identifier)` cruft. Those were dropped as diseases / anatomy / procedures / specialties / people / off-theme rather than padded in, leaving a focused set of excitable-[[Signal|signal]], circuit, decoding, plasticity, development, and motor-control processes plus the electrodiagnostic recordings that measure them. The conduction-study twin was collapsed to one slug (Nerve_conduction_studies → `Nerve_conduction_study`). Thirteen of the eighteen are shared with [[Genomics|GENOMICS]]-Neuroscience and built once by the registry. **A re-crawl is recommended** from the neurophysiology parents — `Action_potential`, `Nerve_conduction_velocity`, `Myelin`, `Reflex_arc`, `Neural_oscillation`, `Tremor`, `Intracranial_pressure` — to surface the wave-and-circuit process articles (the action potential, demyelination, tremor, intracranial-pressure dynamics) this clinical room should also hold but which the specialty crawl never returned.
### Top 10 — start here (10) · *the most canonical, visually striking clinical-neuro sims; build these first*
- [ ] Reflex
- [ ] Nerve conduction study
- [ ] Electroencephalography
- [ ] Neuron
- [ ] Neuroplasticity
- [ ] [[Neural_circuit]]
- [ ] [[Neural_network_(machine_learning)]]
- [ ] Motor control
- [ ] [[Detection_theory]]
- [ ] Development of the nervous system
### Electrodiagnostic signals (2) · *wave / signal sim; record the motor-unit train and the stimulus-locked response*
- [ ] Electromyography
- [ ] Evoked potential
### Circuits, connectomes & neural interfaces (3) · *network / decoding sim; map the wiring, decode the spikes, and close the control loop*
- [ ] [[Connectomics]]
- [ ] Neural decoding
- [ ] Brain–computer interface
### Modulation, development & movement (3) · *process / cycle sim; tune the neuromodulators, grow new neurons, and walk the gait cycle*
- [ ] Neuromodulation
- [ ] Neurogenesis
- [ ] Gait
## E — Epidemiology
Epidemiology is the study of how disease is distributed across populations and what determines that distribution — the science of counting cases, comparing the exposed to the unexposed, and reasoning from association to cause. With endocrinology it is one of the two most microsimmable branches of clinical medicine, because almost none of it is anatomy: it is **dynamics and inference**. An epidemic is a compartmental model — susceptibles draining into the infected pool at a mass-action rate and out into recovery — whose curve a learner can bend by vaccinating, quarantining, distancing, or tracing contacts; an association is a 2×2 table whose odds ratio, relative risk, and attributable fraction shift as the cells are dragged; a diagnostic test is an ROC curve sweeping a threshold across two overlapping distributions; and the whole apparatus of biostatistics — a sampling distribution settling onto the central limit theorem, the spread and shape of a distribution, a regression line fitting a cloud of points, a survival curve stepping down a life table — is parameter-slider material of the purest kind.
**117 articles** selected from the **611** validated candidates by the clinical bar *"is this a dynamic, quantitative process or model, not a named disease, drug, organ, procedure, specialty, organization, or person?"*, grouped by p5.js MicroSim pattern and led by a build-first top-10. The pool was the most heterogeneous in the sheet and most of it — 494 of the 611 — was dropped. The single largest block, the **`Template:Vaccines` product catalog**, went wholesale: roughly a hundred named vaccines from the anthrax, cholera, and BCG vaccines through the COVID-19 roster (Comirnaty, Spikevax, Covaxin, CoronaVac, Sputnik V…), plus their adjuvants, schedules, storage, wastage, injury-compensation programs, and the autism-fraud and hesitancy controversies — all dropped as **drugs / products / events**. The **public-health policy and rights agenda** (universal health care, sanitation and WASH, the pollution roster, housing, family planning, labor and toilet rights, eugenics, harm reduction, and the determinants-of-health and behavioral-theory frameworks) dropped as **policy / off-theme**; the **named diseases** (cholera, smallpox, lung cancer, leptospirosis, the notifiable-disease and STI lists), the **subfield roster** (environmental, occupational, forensic, molecular, genetic, spatial, and veterinary epidemiology, plus the public-health specialties), the **schools, agencies, journals, degrees, and named cohort studies** (Johns Hopkins and the Bloomberg School, the CDC, WHO, ECDC and the national institutes, the Whitehall, British Doctors, Caerphilly, and Pomerania studies), the field's **people** (Snow, Semmelweis, Lister, Pasteur, Ross, Doll, Hill, Salk, Hilleman, Karikó…) and its **history** (miasma theory, humorism, the Great Plague and the 1854 Broad Street outbreak), and the usual `Category:*`, `Template_talk:*`, `List_/Outline_/History_/Timeline_of_*`, and `*_(disambiguation)` cruft — all dropped rather than padded in. The pure-mathematics tail of the statistics navbox (the exotic Heronian, Heinz, Lehmer, contraharmonic, and generalized means, the higher moments and L-moments) was dropped as **off-theme math**, but the **core biostatistics that epidemiology actually runs on** — descriptive measures, dispersion and shape, hypothesis tests and regression, the central limit theorem, survival and life tables — was *kept*, because in this branch the statistics is the science. Synonym and notation twins were collapsed to one slug each (Risk_ratio → `Relative_risk`; Case-control → `Case–control_study`; Cohort_studies → `Cohort_study`; Immunization / Inoculation → `Vaccination`; Mathematical_modelling_of_infectious_diseases → singular; Exposure_Assessment → `Exposure_assessment`; Predictive_analytics → `Predictive_modelling`; Cluster_(epidemiology) → `Disease_cluster`; Epidemiological_method → `Epidemiological_methods`). The sensitivity/specificity topic is built once in Internal medicine (as `Sensitivity_and_specificity`) and is **not** relisted here. Topics shared with other hubs — the modeling and statistical sims, the contact-network and diffusion-of-innovations models — are listed here and built once by the registry.
### Top 10 — start here (10) · *compartment / 2×2 / curve; the most canonical, visually striking epidemiology sims — build these first*
- [ ] Compartmental models in epidemiology
- [ ] Mathematical modelling of infectious disease
- [ ] Contact tracing
- [ ] ROC curve
- [ ] Odds ratio
- [ ] Relative risk
- [ ] Pre- and post-test probability
- [ ] Confounding
- [ ] Life tables
- [ ] Central limit theorem
### Transmission & infectious-disease models (8) · *compartment / mass-action / spatial; seed an index case and watch the epidemic spread through the population*
- [ ] Law of mass action
- [ ] Critical community size
- [ ] Transmission (medicine)
- [ ] Outbreak
- [ ] Epidemic
- [ ] Endemic (epidemiology)
- [ ] Disease diffusion mapping
- [ ] Disease cluster
### Outbreak control & interventions (4) · *parameter toggle; switch on an intervention and watch the reproduction number and the epidemic curve fall*
- [ ] Vaccination
- [ ] Targeted immunization strategies
- [ ] Quarantine
- [ ] Social distancing
### Disease frequency & burden (8) · *rate / counter; tally new and existing cases and read off the rates a population carries*
- [ ] Incidence (epidemiology)
- [ ] Cumulative incidence
- [ ] Point prevalence
- [ ] Period prevalence
- [ ] Case fatality rate
- [ ] Virulence
- [ ] Infectivity
- [ ] Epidemiological transition
### Association & effect measures (11) · *2×2 table / parameter; drag the cells of the contingency table and watch every measure of effect recompute*
- [ ] Risk difference
- [ ] Hazard ratio
- [ ] Relative risk reduction
- [ ] Number needed to treat
- [ ] Number needed to harm
- [ ] Attributable fraction among the exposed
- [ ] Attributable fraction for the population
- [ ] Preventable fraction among the unexposed
- [ ] Preventable fraction for the population
- [ ] Population impact measure
- [ ] Age adjustment
### Causal inference & bias (9) · *DAG / sampling / scoring; introduce a confounder or a biased sample and watch the estimate distort*
- [ ] Causal inference
- [ ] Causal pie model
- [ ] Bradford Hill criteria
- [ ] Selection bias
- [ ] Recall bias
- [ ] Information bias (epidemiology)
- [ ] Correlation does not imply causation
- [ ] Mendelian randomization
- [ ] Survivorship bias
### Observational study designs & methods (13) · *sampling-frame; sample forward from exposure or backward from disease and see how each design reads the population*
- [ ] Epidemiological methods
- [ ] Study design
- [ ] Observational study
- [ ] Cohort study
- [ ] Retrospective cohort study
- [ ] Prospective cohort study
- [ ] Case–control study
- [ ] Nested case–control study
- [ ] Cross-sectional study
- [ ] Longitudinal study
- [ ] Ecological study
- [ ] Case series
- [ ] Case report
### Experiments, trials & evidence synthesis (13) · *randomization / forest plot / flow; randomize a cohort, run the trial, and pool the results up the evidence pyramid*
- [ ] Clinical trials
- [ ] Design of experiments
- [ ] Adaptive clinical trial
- [ ] Scientific control
- [ ] Blind experiment
- [ ] Open-label trial
- [ ] Platform trial
- [ ] Phases of clinical research
- [ ] Intention-to-treat analysis
- [ ] Hierarchy of evidence
- [ ] Systematic review
- [ ] Meta-analysis
- [ ] Reproducibility
### Screening, test accuracy & exposure (6) · *ROC / 2×2 / matrix; sweep a diagnostic threshold and map exposures to outcomes*
- [ ] Screening (medicine)
- [ ] Likelihood ratios in diagnostic testing
- [ ] [[Accuracy_and_precision]]
- [ ] Predictive modelling
- [ ] Exposure assessment
- [ ] Job-exposure matrix
### Biostatistics I — distributions & central tendency (13) · *data-drag / parameter; drop data points and watch the average, the histogram, and the distribution respond*
- [ ] Descriptive statistics
- [ ] Central tendency
- [ ] Mean
- [ ] Arithmetic mean
- [ ] Median
- [ ] Mode (statistics)
- [ ] Geometric mean
- [ ] Harmonic mean
- [ ] Continuous probability distribution
- [ ] [[Probability]]
- [ ] Frequency distribution
- [ ] Count data
- [ ] Contingency table
### Biostatistics II — dispersion & shape (12) · *spread / shape slider; widen the spread and skew the curve and watch every summary statistic move*
- [ ] Statistical dispersion
- [ ] Standard deviation
- [ ] Variance
- [ ] Coefficient of variation
- [ ] Interquartile range
- [ ] Percentile
- [ ] Range (statistics)
- [ ] Average absolute deviation
- [ ] Index of dispersion
- [ ] Shape of the distribution
- [ ] Skewness
- [ ] Kurtosis
### Inferential statistics & regression (6) · *hypothesis-test / curve-fit; set a null, draw a sample, and fit a line through the data*
- [ ] Statistical hypothesis testing
- [ ] Analysis of variance
- [ ] Regression analysis
- [ ] Poisson regression
- [ ] Student's t-test
- [ ] Z-test
### Survival, mortality & behavioral spread (4) · *survival curve / S-curve; step a cohort down a life table and watch an idea diffuse through a population*
- [ ] Infant mortality
- [ ] Child mortality
- [ ] Adult mortality
- [ ] [[Diffusion_of_innovations]]
---
## How to use this worklist
1. **Lease the branch.** `python3 ../MicroSim-Registry/microsim_registry.py branch-acquire --page Medicine --branch "<Letter> — <Name>"`.
2. **Populate it** per `../MicroSim-Registry/BRANCH-BUILD-METHOD.md` — flipped columns (parent = col A, link = col B). Drop named diseases, syndromes, drugs, anatomy, procedures, and people; keep physiological processes, dynamics, and models. Group by pattern with a build-first top-10.
3. **Build, register & release.** `scan --write`, then `branch-release --built`. `check` is the collision gate.
```dataview
TABLE status, editor_url FROM "Articles" WHERE contains(file.folder, "Medicine") SORT status
```
---
_Seed: the **M.E.D.I.C.I.N.E.** sheet (2,866 validated links) · all 8 branches built/queued (M re-crawled from Microbiology, shared with GENOMICS) · one article per topic enforced vault-wide by MicroSim-Registry._
---
<!-- HYDRO-BRIDGE:START -->
## 🌊 Hydrodynamics image bridges (8)
*Back-links from the Hydrodynamics Image Atlas — the 8 water images that bridge into **MEDICINE**. The atlas forward-links this hub; these are the return path. The Water Room is the corpus's most interconnected node.*
- №65 · Aneurysm / arterial stenosis flow
- №66 · IV gravity drip (Poiseuille dosing)
- №67 · Nebulizer / atomizer
- №68 · Blood viscosity & hematocrit
- №69 · Heart-valve flow (Doppler echo)
- №70 · Hemodialysis circuit
- №71 · Respiratory airflow (spirometry)
- №72 · Stent / catheter hemodynamics
Parent flow: Hydrodynamics Portal · Image Atlas (100) · Water Room.
<!-- HYDRO-BRIDGE:END -->
<!-- BEAUTY-PASS-MEDIA:START -->
## Wikipedia : Wikitube
**Strict pair:** [Wikipedia](https://en.wikipedia.org/wiki/Medicine) : [Wikitube](https://en.wikitube.io/wiki/Medicine)
## Previous hub tags
Tree parents: [[Dynamical_system]] · [[Oxygen]].
Legacy hubs: `MEDICINE`.
---
*Sources: 2 legacy notes. Minted wave 1, 2026-07-30 (v1.6 order).*